2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione

Base Information

Chemical Name:2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione
CAS No.:139528-39-5
Molecular Formula:C₂₂H₂₇N₃O₂
Molecular Weight:365.475
Hs Code.:

Synonyms:2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione

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Technology Process of 2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione

There total 4 articles about 2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 85-44-9
phthalic anhydride

: 130563-29-0
(1R,2S)-α-<1-<<2-(dimethylamino)ethyl>methylamino>ethyl>benzylamine

: 139528-39-5
2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione

Guidance literature:: In toluene; for 12h; Heating;
DOI:10.1021/jo00032a013

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 139528-39-5
2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: Na₂CO₃, NaI / benzene / 20 h / Heating

2: 1) MsCl, NEt₃, 2) NaN₃ / 1) THF, 0 deg C, 1h, 2) HMPA, 80 deg C, 12h

3: LiAlH₄ / tetrahydrofuran / 10 h / Heating

4: 75 percent / toluene / 12 h / Heating

With lithium aluminium tetrahydride; sodium azide; sodium carbonate; methanesulfonyl chloride; triethylamine; sodium iodide; In tetrahydrofuran; toluene; benzene;
DOI:10.1021/jo00032a013

Reference yield:

: 130753-27-4
(1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide

: 139528-39-5
2-{(1R,2S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-propyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1) MsCl, NEt₃, 2) NaN₃ / 1) THF, 0 deg C, 1h, 2) HMPA, 80 deg C, 12h

2: LiAlH₄ / tetrahydrofuran / 10 h / Heating

3: 75 percent / toluene / 12 h / Heating

With lithium aluminium tetrahydride; sodium azide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jo00032a013