2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester

Base Information

Chemical Name:2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester
CAS No.:164166-95-4
Molecular Formula:C₄₅H₃₉N₃O₂
Molecular Weight:653.824
Hs Code.:

Synonyms:2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester

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Chemical Property of 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester

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Technology Process of 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester

There total 3 articles about 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 76-83-5
trityl chloride

: 4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9
(R)-histidine methyl ester dihydrochloride

: 164166-95-4
2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester

Guidance literature:: With triethylamine; In acetonitrile; Ambient temperature;
DOI:10.1021/jm980408v

Reference yield:

: D-Histidine dihydrochloride

: 164166-95-4
2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / SOCl₂ / 60 °C

2: 100 percent / Et₃N / acetonitrile / Ambient temperature

With thionyl chloride; triethylamine; In acetonitrile;
DOI:10.1021/jm980408v

Reference yield:

: 351-50-8
D-histidin

: 164166-95-4
2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-D-histidine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 20 °C

1.2: 60 °C

2.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/acs.jmedchem.8b01007