6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid

Base Information

Chemical Name:6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid
CAS No.:1150098-20-6
Molecular Formula:C₁₅H₁₁F₂IN₂O₃
Molecular Weight:432.165
Hs Code.:

Synonyms:6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid

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Chemical Property of 6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid

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Technology Process of 6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid

There total 1 articles about 6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1150098-23-9
7-chloro-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

: 29632-74-4
2-fluro-4-iodoaniline

: 1150098-20-6
6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid

Guidance literature:: 2-fluro-4-iodoaniline; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

7-chloro-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield: 82.9%

: 934666-39-4,934666-06-5
1,1-dimethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate

: 1150098-20-6
6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid

: 1193488-62-8
(S)-2-{1-[6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carbonyl]-3-hydroxy-azetidin-3-yl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

1,1-dimethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;