(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-3-(piperidin-4-yl)propyl oxime

Base Information

Chemical Name:(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-3-(piperidin-4-yl)propyl oxime
CAS No.:1433607-08-9
Molecular Formula:C₂₈H₃₃FN₆O
Molecular Weight:488.608
Hs Code.:

Synonyms:(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-3-(piperidin-4-yl)propyl oxime

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Chemical Property of (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-3-(piperidin-4-yl)propyl oxime

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Technology Process of (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-3-(piperidin-4-yl)propyl oxime

There total 2 articles about (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-3-(piperidin-4-yl)propyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1433607-15-8
(E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)propyl)piperidine

: 1433607-08-9
(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-3-(piperidin-4-yl)propyl oxime

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

: 1433605-21-0
(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

: 164149-27-3
tert-butyl 4-(3-bromopropyl)piperidine-1-carboxylate

: 1433607-08-9
(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-3-(piperidin-4-yl)propyl oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

1.2: 2 h / 60 °C

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;