7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

Base Information

• Chemical Name: 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• CAS No.: 114915-20-7
• Molecular Formula: C₄₃H₅₃NO₁₄
• Molecular Weight: 807.892
• Mol file: 114915-20-7.mol

Synonyms:7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.

Chemical Property of 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

Chemical Property:

• PSA: 224.45000
• LogP: 3.65050

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

There total 133 articles about 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate (133524-69-3,133577-36-3,133577-37-4) → Docetaxel (114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0)

Guidance literature:

Reference yield: 92.8%

2'-acetyldocetaxel (151509-27-2) → Docetaxel (114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0)

Guidance literature:

With dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1002/cjoc.201201142

Reference yield: 90.0%

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel (114915-14-9) → Docetaxel (114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0)

Guidance literature:

With acetic acid; zinc; In methanol; at 60 ℃; for 2h;

DOI:10.1016/S0040-4020(01)81313-2

upstream raw materials:

di-tert-butyl dicarbonate

C₃₈H₄₅NO₁₂

7,10-di(2,2,2-trichloroethyloxy-carbonyl)-13-cinnamoyl-10-deacetyl baccatin III

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

Downstream raw materials:

2'-acetyldocetaxel

2',10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

docetaxel/mono propylene glycol clathrate