2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide

Base Information

• Chemical Name: 2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide
• CAS No.: 96240-30-1
• Molecular Formula: C₁₁H₁₃N₅O₃
• Molecular Weight: 263.256
• Mol file: 96240-30-1.mol

Synonyms:2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide

Chemical Property of 2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide

There total 3 articles about 2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetic acid ethyl ester (96240-15-2) → 2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide (96240-30-1)

Guidance literature:

With ammonia; In ethanol; at 0 ℃; for 120h;

DOI:10.1002/jhet.5570210641

Reference yield:

N(1)-Carbethoxyhydrazon von Ethyl-p-methoxybenzoat (70249-87-5) → 2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide (96240-30-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / butan-1-ol / 30 h / Heating

2: 1)EtONa / 1)EtOh, reflux 2h 2)70-80 deg C, 8h

3: 83 percent / NH₃ / ethanol / 120 h / 0 °C

With ammonia; sodium ethanolate; hydrazine hydrate; In ethanol; butan-1-ol;

DOI:10.1002/jhet.5570210641

Reference yield:

4-amino-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one (70249-92-2) → 2-[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetamide (96240-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1)EtONa / 1)EtOh, reflux 2h 2)70-80 deg C, 8h

2: 83 percent / NH₃ / ethanol / 120 h / 0 °C

With ammonia; sodium ethanolate; In ethanol;

DOI:10.1002/jhet.5570210641

upstream raw materials:

[4-Amino-3-(4-methoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-acetic acid ethyl ester

N⁽¹⁾-Carbethoxyhydrazon von Ethyl-p-methoxybenzoat

4-amino-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one