2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid

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Chemical Name:2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid
CAS No.:937060-75-8
Molecular Formula:C₂₈H₃₀ClN₅O₆
Molecular Weight:568.029
Hs Code.:

Synonyms:2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid

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Chemical Property of 2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid

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Technology Process of 2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid

There total 15 articles about 2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 937060-71-4
methyl 2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoate

: 937060-75-8
2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid

Guidance literature:: methyl 2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoate; With potassium carbonate; In tetrahydrofuran; methanol; water; at 20 ℃; Heating;

With acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-69-7
2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethanol

: 937060-75-8
2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 0 °C

2: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3: potassium carbonate / tetrahydrofuran; methanol; water / 20 °C / Heating

With tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937063-59-7
methyl 2-methyl-2-(2-oxoethoxy)propanoate

: 937060-75-8
2-[(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)methoxy]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium chlorite; sodium dihydrogenphosphate dihydrate; aminosulfonic acid / water; tert-butyl alcohol / 20 °C / Cooling with ice

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 20 °C

3: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 0 - 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

5: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

6: potassium carbonate / tetrahydrofuran; methanol; water / 20 °C / Heating

With sodium chlorite; sodium azide; sodium dihydrogenphosphate dihydrate; trifluoromethylsulfonic anhydride; aminosulfonic acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.02.054