2-amino-3-{4-[2-(4-amino-phenyl)-2H-tetrazol-5-yl]-phenyl}-propionic acid

Base Information

• Chemical Name: 2-amino-3-{4-[2-(4-amino-phenyl)-2H-tetrazol-5-yl]-phenyl}-propionic acid
• CAS No.: 1184247-61-7
• Molecular Formula: C₁₆H₁₆N₆O₂
• Molecular Weight: 324.342

Synonyms:2-amino-3-{4-[2-(4-amino-phenyl)-2H-tetrazol-5-yl]-phenyl}-propionic acid

Chemical Property of 2-amino-3-{4-[2-(4-amino-phenyl)-2H-tetrazol-5-yl]-phenyl}-propionic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-amino-3-{4-[2-(4-amino-phenyl)-2H-tetrazol-5-yl]-phenyl}-propionic acid

There total 1 articles about 2-amino-3-{4-[2-(4-amino-phenyl)-2H-tetrazol-5-yl]-phenyl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-{4-[2-(4-acetylamino-phenyl)-2H-tetrazol-5-yl]-phenyl}-2-tert-butoxycarbonylamino-propionic acid methyl ester (1184247-88-8) → 2-amino-3-{4-[2-(4-amino-phenyl)-2H-tetrazol-5-yl]-phenyl}-propionic acid (1184247-61-7)

Guidance literature:

3-{4-[2-(4-acetylamino-phenyl)-2H-tetrazol-5-yl]-phenyl}-2-tert-butoxycarbonylamino-propionic acid methyl ester; With boron tribromide; In dichloromethane; at -78 - 20 ℃;

With hydrogenchloride; In methanol; water; Reflux;

DOI:10.1021/ol901300h

Reference yield:

2-amino-3-{4-[2-(4-amino-phenyl)-2H-tetrazol-5-yl]-phenyl}-propionic acid (1184247-61-7) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → 5-[4-(2-amino-2-carboxy-ethyl)-phenyl]-2-(4-amino-phenyl)-3-methyl-3,4-dihydro-2H-pyrazole-3-carboxylic acid methyl ester (1184247-74-2)

Guidance literature:

In acetonitrile; for 3h; regioselective reaction; aq. PBS buffer; Inert atmosphere; UV-irradiation;

DOI:10.1021/ol901300h

upstream raw materials:

3-{4-[2-(4-acetylamino-phenyl)-2H-tetrazol-5-yl]-phenyl}-2-tert-butoxycarbonylamino-propionic acid methyl ester

Downstream raw materials:

5-[4-(2-amino-2-carboxy-ethyl)-phenyl]-2-(4-amino-phenyl)-3-methyl-3,4-dihydro-2H-pyrazole-3-carboxylic acid methyl ester

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