5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

Base Information

Chemical Name:5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one
CAS No.:264600-49-9
Molecular Formula:C₂₅H₂₄Cl₃FN₄O₈
Molecular Weight:633.845
Hs Code.:

5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

Synonyms:5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

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Chemical Property of 5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

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Technology Process of 5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

There total 3 articles about 5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 264600-47-7
5(R)[isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)-aminomethyl]-[3-fluoro-4-(1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

: 13831-31-7
Acetoxyacetyl chloride

: 264600-49-9
5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

Guidance literature:: With sodium hydrogencarbonate; In water; acetone; at 0 ℃; for 0.25h;

Reference yield:

: 264600-46-6
5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-benzyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

: 264600-49-9
5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

2: sodium hydrogencarbonate / water; acetone / 0.25 h / 0 °C

With carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetone;

Reference yield:

: 264600-44-4
3-(2,2,2-trichloroethyloxycarbonylamino)isoxazole

: 264600-49-9
5(R)-[N-isoxazol-3-yl-N-(2,2,2-trichloroethyloxycarbonyl)aminomethyl]-3-[3-fluoro-4-(1-acetoxyacetyl-1,2,5,6-tetrahydropyrid-4-yl)phenyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 48.5 h / 0 - 20 °C

2: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: sodium hydrogencarbonate / water; acetone / 0.25 h / 0 °C

With tributylphosphine; carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; water; acetone;