5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide
CAS No.:1354955-70-6
Molecular Formula:C₁₅H₉Cl₂F₄NO₄S
Molecular Weight:446.206
Hs Code.:

Synonyms:5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide

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Chemical Property of 5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide

Chemical Property:

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Technology Process of 5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide

There total 7 articles about 5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 3144-09-0
methanesulfonamide

: 1354962-95-0
4-methylphenyl 5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluorobenzoate

: 1354955-70-6
5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide

Guidance literature:: methanesulfonamide; With sodium hydride; In 2-methyltetrahydrofuran; at 0 - 20 ℃; for 1h;

4-methylphenyl 5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluorobenzoate; In 2-methyltetrahydrofuran; at 65 ℃; for 6h;

Reference yield: 34.0%

: 3144-09-0
methanesulfonamide

: 1354960-86-3
5-chloro-4-(4-chloro-3-(trifluoromethyl)phenoxy)-2-fluorobenzoic acid

: 1354955-70-6
5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide

Guidance literature:: 5-chloro-4-(4-chloro-3-(trifluoromethyl)phenoxy)-2-fluorobenzoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

methanesulfonamide; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 5-chloro-2,4-difluorobenzoic acid

: 1354955-70-6
5-chloro-4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-fluoro-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 5 h / 60 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 16.16 h / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / dimethyl sulfoxide / 2 h / 15 - 25 °C

4.1: sodium hydride / 2-methyltetrahydrofuran / 1 h / 0 - 20 °C

4.2: 6 h / 65 °C

With thionyl chloride; sodium hydride; potassium carbonate; triethylamine; In 2-methyltetrahydrofuran; dichloromethane; dimethyl sulfoxide;