7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

Base Information

Chemical Name:7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile
CAS No.:1315503-82-2
Molecular Formula:C₁₈H₁₅NO₅
Molecular Weight:325.321
Hs Code.:

Synonyms:7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

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Chemical Property of 7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

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Technology Process of 7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

There total 10 articles about 7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1315504-07-4
7-(benzyloxy)-4-hydroxy-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

: 107-30-2
chloromethyl methyl ether

: 1315503-82-2
7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja205339p

Reference yield:

: C₂₂H₂₅NO₄Si

: 1315503-82-2
7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja205339p

Reference yield:

: C₁₆H₁₇NO₃

: 1315503-82-2
7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; triethylamine / dichloromethane

2: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / -78 - -60 °C

3: potassium cyanide; 18-crown-6 ether / dichloromethane / 2 h / 0 °C

4: acetic acid / 10 h / 0 °C

5: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; potassium cyanide; 18-crown-6 ether; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; tert.-butyl lithium; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja205339p