Technology Process of 7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile
There total 10 articles about 7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1021/ja205339p
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
With
tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja205339p
- Guidance literature:
-
Multi-step reaction with 6 steps
1: dmap; triethylamine / dichloromethane
2: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / -78 - -60 °C
3: potassium cyanide; 18-crown-6 ether / dichloromethane / 2 h / 0 °C
4: acetic acid / 10 h / 0 °C
5: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
With
dmap; potassium cyanide; 18-crown-6 ether; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; tert.-butyl lithium; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja205339p
