1-(4-fluorobenzyl)-5-nitroindoline

Base Information

Chemical Name:1-(4-fluorobenzyl)-5-nitroindoline
CAS No.:790677-21-3
Molecular Formula:C₁₅H₁₃FN₂O₂
Molecular Weight:272.279
Hs Code.:

Synonyms:1-(4-fluorobenzyl)-5-nitroindoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorobenzyl)-5-nitroindoline

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Technology Process of 1-(4-fluorobenzyl)-5-nitroindoline

There total 2 articles about 1-(4-fluorobenzyl)-5-nitroindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.2%

: 790677-21-3
1-(4-fluorobenzyl)-5-nitroindoline

Guidance literature:

Reference yield: 65.0%

: 32692-19-6
5-nitro-2,3-dihydro-1H-indole

: 459-57-4
4-fluorobenzaldehyde

: 790677-21-3
1-(4-fluorobenzyl)-5-nitroindoline

Guidance literature:: 5-nitro-2,3-dihydro-1H-indole; 4-fluorobenzaldehyde; With acetic acid; In dichloromethane; for 1.5h; Reflux;

With sodium tris(acetoxy)borohydride; In dichloromethane; Reflux;
DOI:10.1021/acs.jmedchem.9b00796

Reference yield: 98.0%

: 790677-21-3
1-(4-fluorobenzyl)-5-nitroindoline

: 1-(4-fluorobenzyl)indolin-5-amine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 30 ℃; under 7500.75 Torr;
DOI:10.1021/acs.jmedchem.9b00796