1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole

Base Information

Chemical Name:1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole
CAS No.:1446281-87-3
Molecular Formula:C₂₆H₃₅N₃O₂
Molecular Weight:421.583
Hs Code.:

Synonyms:1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole

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Chemical Property of 1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole

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Technology Process of 1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole

There total 7 articles about 1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1446281-98-6
N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-4-propoxyphenyl)-2-piperidylacetamide

: 1446281-87-3
1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole

Guidance literature:: With acetic acid; at 100 ℃; for 6h;

Reference yield:

: 610-81-1
4-hydroxy-2-nitroaniline

: 1446281-87-3
1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide monohydrate / ethanol / 70 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6.25 h / 20 °C

3: tetrahydrofuran / 6 h / 50 °C

4: hydrogen; palladium 10% on activated carbon / ethanol / 4 h / 3102.97 Torr

5: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 110 °C

6: acetic acid / 6 h / 100 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1446281-96-4
N-(2-nitro-4-propoxyphenyl)-2-piperidylacetamide

: 1446281-87-3
1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-6-propoxy-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 4 h / 3102.97 Torr

2: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 110 °C

3: acetic acid / 6 h / 100 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; potassium iodide; In ethanol; N,N-dimethyl-formamide;