Methanone, [4-[(2-aminophenyl)ethynyl]phenyl]phenyl-

Base Information

Chemical Name:Methanone, [4-[(2-aminophenyl)ethynyl]phenyl]phenyl-
CAS No.:124643-46-5
Molecular Formula:C₂₁H₁₅NO
Molecular Weight:297.356
Hs Code.:
DSSTox Substance ID:DTXSID501217633

Synonyms:Methanone, [4-[(2-aminophenyl)ethynyl]phenyl]phenyl-;DTXSID501217633;124643-46-5

Suppliers and Price of Methanone, [4-[(2-aminophenyl)ethynyl]phenyl]phenyl-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanone, [4-[(2-aminophenyl)ethynyl]phenyl]phenyl-

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:297.115364102
Heavy Atom Count:23
Complexity:457

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)C#CC3=CC=CC=C3N

Technology Process of Methanone, [4-[(2-aminophenyl)ethynyl]phenyl]phenyl-

There total 2 articles about Methanone, [4-[(2-aminophenyl)ethynyl]phenyl]phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 52670-38-9
2-ethynylaniline

: 124643-34-1
p-benzoylphenyl triflate

: 124643-46-5
[4-(2-Amino-phenylethynyl)-phenyl]-phenyl-methanone

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 90 ℃; for 1h;
DOI:10.1016/S0040-4039(01)80456-1

Reference yield:

: 615-43-0
2-iodophenylamine

: 124643-46-5
[4-(2-Amino-phenylethynyl)-phenyl]-phenyl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CuI, Et₂NH; 2.) KF*2H₂O / 1.) Pd(PPh₃)4 / 1.) DMF, room temp., 6h; 2.) MeOH, room temp., 7h

2: 85 percent / Et₃N / PdCl₂(PPh₃)2 / dimethylformamide / 1 h / 90 °C

With potassium fluoride; copper(l) iodide; diethylamine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)80456-1