4-Methyl-2,6-diacetylpyridine

Base Information

• Chemical Name: 4-Methyl-2,6-diacetylpyridine
• CAS No.: 114578-66-4
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.203
• DSSTox Substance ID: DTXSID50553071
• Wikidata: Q82433563
• Mol file: 114578-66-4.mol

Synonyms:114578-66-4;4-METHYL-2,6-DIACETYLPYRIDINE;1,1'-(4-Methylpyridine-2,6-diyl)diethanone;1-(6-ACETYL-4-METHYLPYRIDIN-2-YL)ETHANONE;SCHEMBL5370102;1,1'-(4-METHYL-2,6-PYRIDINEDIYL)BIS-ETHANONE;DTXSID50553071;AKOS006308039;AB62706;1,1'-(4-Methylpyridine-2,6-diyl)di(ethan-1-one);J-400626

Chemical Property of 4-Methyl-2,6-diacetylpyridine

Chemical Property:

• Boiling Point: 320.6°Cat760mmHg
• Flash Point: 152.1°C
• PSA: 47.03000
• Density: 1.093g/cm³
• LogP: 1.79520
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 177.078978594
• Heavy Atom Count: 13
• Complexity: 203

Purity/Quality:

1,1'-(4-METHYL-2,6-PYRIDINEDIYL)BIS-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=C1)C(=O)C)C(=O)C

Technology Process of 4-Methyl-2,6-diacetylpyridine

There total 2 articles about 4-Methyl-2,6-diacetylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-acetyl-4a,7a-dihydro-4a,6-dimethyl-4H-furo<2,3-e>-1,2-oxazine (114578-61-9) → 2,6-diacetyl-4-methylpyridine (114578-66-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 16h; Ambient temperature;

Reference yield:

2,5-dimethylfuran (625-86-5) → 2,6-diacetyl-4-methylpyridine (114578-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / sodium carbonate / CH₂Cl₂ / 24 h

2: 83 percent / DBU / CH₂Cl₂ / 16 h / Ambient temperature

With sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;

upstream raw materials:

3-acetyl-4a,7a-dihydro-4a,6-dimethyl-4H-furo<2,3-e>-1,2-oxazine

2,5-dimethylfuran