2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine

Base Information

Chemical Name:2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine
CAS No.:127489-99-0
Molecular Formula:C₂₃H₂₂N₂O₄
Molecular Weight:390.439
Hs Code.:

Synonyms:2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine

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Chemical Property of 2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine

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Technology Process of 2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine

There total 4 articles about 2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 91-10-1
1,3-dimethoxy-2-hydroxy-benzene

: 127503-12-2
Methanesulfonic acid (4R,5R)-5-phenyl-2-pyridin-2-yl-4,5-dihydro-oxazol-4-ylmethyl ester

: 127489-99-0
2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine

Guidance literature:: With sodium hydroxide; Aliquat 336; In benzene; for 24h; Heating;
DOI:10.1016/S0040-4039(01)93469-0

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 127489-99-0
2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MeONa / 1.) MeOH; 2.) CH₂Cl₂, reflux, 2h

2: 92 percent / NEt₃ / CH₂Cl₂ / 3 h / -5 °C

3: 68 percent / NaOH, Aliquat 336 / benzene / 24 h / Heating

With sodium hydroxide; sodium methylate; Aliquat 336; triethylamine; In dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)93469-0

Reference yield:

: 46032-98-8
(1R,2R)-2-amino-1-phenylpropane-1,3-diol

: 127489-99-0
2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MeONa / 1.) MeOH; 2.) CH₂Cl₂, reflux, 2h

2: 92 percent / NEt₃ / CH₂Cl₂ / 3 h / -5 °C

3: 68 percent / NaOH, Aliquat 336 / benzene / 24 h / Heating

With sodium hydroxide; sodium methylate; Aliquat 336; triethylamine; In dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)93469-0