11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Base Information

Chemical Name:11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester
CAS No.:321659-09-0
Molecular Formula:C₄₈H₈₂N₆O₉S₂
Molecular Weight:951.346
Hs Code.:

11-[3-(4-<i>tert</i>-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-<i>tert</i>-butyl ester

Synonyms:11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

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Chemical Property of 11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

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Technology Process of 11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

There total 9 articles about 11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 321658-90-6
4-tert-Butoxycarbonyl-1,7-dithia-4,11-diazacyclotetradecane

: 321658-97-3
11-(3-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

: 321659-09-0
11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: With sodium carbonate; sodium iodide; In acetonitrile; for 24h; Heating;
DOI:10.1039/b004797j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 321659-09-0
11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / aq. NaOH / CH₂Cl₂ / 12 h / 20 °C

2: 82 percent / dimethylformamide / 72 h / 20 °C

3: 72 percent / sodium methoxide / 0.08 h / 20 °C

4: 66 percent / potassium iodide; caesium carbonate / dimethylformamide / 60 h / 85 °C

5: 97 percent / ptassium carbonate / benzene / 12 h / Heating

6: 75 percent / Zn; glacial acetic acid / 2 h / 20 °C

7: 65 percent / sodium carbonate; sodium iodide / acetonitrile / 24 h / Heating

With sodium hydroxide; sodium methylate; sodium carbonate; potassium carbonate; caesium carbonate; acetic acid; potassium iodide; sodium iodide; zinc; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1039/b004797j

Reference yield:

: 63024-77-1
3-(Chloromethyl)benzoyl chloride

: 321659-09-0
11-[3-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

2: 65 percent / sodium carbonate; sodium iodide / acetonitrile / 24 h / Heating

With sodium carbonate; triethylamine; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1039/b004797j