2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine

Base Information

Chemical Name:2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine
CAS No.:750594-25-3
Molecular Formula:C₂₂H₂₇N₃O₃S
Molecular Weight:413.541
Hs Code.:

Synonyms:2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine

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Chemical Property of 2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine

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Technology Process of 2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine

There total 4 articles about 2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 622-78-6
Benzyl isothiocyanate

: 374092-84-9
2-amino-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine

: 750594-25-3
2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine

Guidance literature:: In ethanol; for 8h; Heating;
DOI:10.1023/B:COHC.0000008266.92949.ba

Reference yield:

: 13606-58-1
2-methyl-2-ethyltetrahydropyran-4-one

: 750594-25-3
2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / p-TsOH / toluene / Heating

2: 80 percent / tetrahydrofuran / 16 h / 20 °C

3: 76 percent / aq. NH₃ / tetrahydrofuran / 6 h / 50 °C

4: 60 percent / ethanol / 8 h / Heating

With ammonium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; toluene;
DOI:10.1023/B:COHC.0000008266.92949.ba

Reference yield:

: 750594-24-2
2-ethyl-2-methyltetrahydropyran-4-one pyrrolidinyl enamine

: 750594-25-3
2-(N'-benzylthioureido)-3-carbethoxy-7-ethyl-7-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / tetrahydrofuran / 16 h / 20 °C

2: 76 percent / aq. NH₃ / tetrahydrofuran / 6 h / 50 °C

3: 60 percent / ethanol / 8 h / Heating

With ammonium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1023/B:COHC.0000008266.92949.ba