ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Base Information

Chemical Name:ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate
CAS No.:1135294-65-3
Molecular Formula:C₃₁H₃₃NO₅
Molecular Weight:499.607
Hs Code.:

Synonyms:ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

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Chemical Property of ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

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Technology Process of ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

There total 6 articles about ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 901113-92-6
ethyl 3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionate

: 1135294-71-1
5-benzoyl-3-methyl-1H-indole

: 1135294-65-3
ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Guidance literature:: 5-benzoyl-3-methyl-1H-indole; With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

ethyl 3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionate; In N,N-dimethyl-formamide; for 15h; Reflux;
DOI:10.1002/cmdc.201200316

Reference yield:

: C₁₅H₁₉ClO₄

: 1135294-65-3
ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 760.05 Torr

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2.2: 15 h / Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200316

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1135294-65-3
ethyl 3-{4-[2-(5-benzoyl-3-methylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 20 °C / Cooling with ice

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 70 °C / Inert atmosphere

3.1: potassium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

3.2: 0.33 h / -78 °C

4.1: tetrahydrofuran; mineral oil; pentane / -78 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

5.2: 15 h / Reflux

With lithium aluminium tetrahydride; potassium hydride; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1002/cmdc.201200316