(2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Base Information

Chemical Name:(2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
CAS No.:1231747-11-7
Molecular Formula:C₂₅H₃₂FN₆O₈P
Molecular Weight:594.537
Hs Code.:

(2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Synonyms:(2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

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Technology Process of (2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

There total 5 articles about (2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (2S)cyclopentyl 2-((((3R,4R,5R) 5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

: 1231747-11-7
(2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 3.5h; under 760.051 Torr;

Reference yield:

: 2'-deoxy-2'-fluoro-2'-C-methylguanosine

: 261909-90-4
(2S)-cyclopentyl 2-((chloro(phenoxy)phosphoryl)amino)propanoate

: 1231747-11-7
(2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ml100209f

Reference yield:

: ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

: 1231747-11-7
(2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-hydroxy-9H-purin9yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C

2: sodium methylate; 2-hydroxyethanethiol / methanol / Heating

3: 1-methyl-1H-imidazole / tetrahydrofuran / 0 - 20 °C

With 1-methyl-1H-imidazole; sodium methylate; triphenylphosphine; 2-hydroxyethanethiol; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1021/ml100209f