2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide

Base Information

• Chemical Name: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide
• CAS No.: 401891-53-0
• Molecular Formula: C₂₄H₁₈Cl₂F₆N₂O
• Molecular Weight: 535.316
• Mol file: 401891-53-0.mol

Synonyms:2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide

Chemical Property of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide

There total 3 articles about 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride (289686-69-7) + [6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-methyl-amine → 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide (401891-53-0)

Guidance literature:

[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-methyl-amine; With potassium hexamethylsilazane; In tetrahydrofuran; at 20 ℃; for 0.5h;

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield: 82.0%

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride (289686-69-7) → 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide (401891-53-0)

Guidance literature:

[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-methyl-amine; With potassium hexamethylsilazane; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride (289686-69-7) + [6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-methyl-amine → 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide (401891-53-0)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran;

upstream raw materials:

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride