5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

Base Information

Chemical Name:5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile
CAS No.:1058194-06-1
Molecular Formula:C₃₀H₂₆NOP
Molecular Weight:447.516
Hs Code.:

5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ<sup>5</sup>-phosphanylidene)pentanenitrile

Synonyms:5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

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Chemical Property of 5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

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Technology Process of 5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

There total 6 articles about 5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1058193-98-8
C₃₀H₂₄NOP

: 1058194-06-1
5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; for 10h; under 760.051 Torr; Inert atmosphere;
DOI:10.5012/bkcs.2010.31.10.2776

Reference yield: 82.0%

: 1528745-21-2
5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

: 1058194-06-1
5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; N,N-dimethyl-formamide; at 0 ℃; for 5h; Inert atmosphere;
DOI:10.5012/bkcs.2013.34.10.2953

Reference yield:

: 16640-68-9
cyanomethylene triphenylphosphorane

: 1058194-06-1
5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 3.5 h / 0 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 10 h / 760.05 Torr / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; mineral oil; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination;
DOI:10.5012/bkcs.2010.31.10.2776