carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester

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Chemical Name:carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester
CAS No.:910055-76-4
Molecular Formula:C₃₁H₅₀N₂O₁₂
Molecular Weight:642.744
Hs Code.:

carbonic acid 3-<i>tert</i>-butoxycarbonylamino-6-({<i>tert</i>-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester <i>tert</i>-butyl ester

Synonyms:carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester

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Chemical Property of carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester

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Technology Process of carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester

There total 11 articles about carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 910055-75-3
acetic acid 3-{4-[tert-butoxycarbonyl-(5-tert-butoxycarbonylamino-6-tert-butoxycarbonyloxy-3,4-dihydroxy-tetrahydro-pyran-2-ylmethyl)-amino]-butoxy}-phenyl ester

: 910055-76-4
carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester

Guidance literature:: With methanol; sodium methylate; at 20 ℃; for 2h;
DOI:10.1021/ol060783e

Reference yield:

: 910055-73-1
3-(4-iodobutoxy)phenyl acetate

: 910055-76-4
carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / N,N-diisopropylethylamine / acetonitrile / 14 h / 80 °C

2: 95 percent / Et₃N / methanol / 5 h / 20 °C

3: 98 percent / NaOMe; MeOH / 2 h / 20 °C

With methanol; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;
DOI:10.1021/ol060783e

Reference yield:

: 178158-23-1
N-Cbz-D-glucosamine

: 910055-76-4
carbonic acid 3-tert-butoxycarbonylamino-6-({tert-butoxycarbonyl-[4-(3-hydroxy-phenoxy)-butyl]-amino}-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.65 g / Et₃N; DMAP / dioxane; H₂O / 24 h / 20 °C

2: 87 percent / pyridine / 0 - 20 °C

3: 94 percent / NaH / dimethylformamide / 16 h / 80 °C

4: 74 percent / PPh₃; H₂O / tetrahydrofuran / 14 h / 20 °C

5: 67 percent / N,N-diisopropylethylamine / acetonitrile / 14 h / 80 °C

6: 95 percent / Et₃N / methanol / 5 h / 20 °C

7: 98 percent / NaOMe; MeOH / 2 h / 20 °C

With pyridine; methanol; dmap; water; sodium methylate; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol060783e