N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide

Base Information

Chemical Name:N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide
CAS No.:1333316-43-0
Molecular Formula:C₂₅H₂₅IN₄O₃
Molecular Weight:556.403
Hs Code.:

Synonyms:N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide

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Chemical Property of N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide

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Technology Process of N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide

There total 4 articles about N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.7%

: C₁₈H₂₂N₄O₂*(x)ClH

: 618-51-9
3-Iodobenzoic acid

: 1333316-43-0
N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 66.0%

: 1416549-11-5
N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1333316-43-0
N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide

Guidance literature:: With copper(I) oxide; 1,10-Phenanthroline; potassium iodide; In methanol; water; at 80 ℃; for 1h; High pressure;
DOI:10.1021/ol303164h

Reference yield:

: 1215900-43-8
C₁₈H₂₂N₄O₂

: 1333316-43-0
N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-iodobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane

1.2: 5 h / 20 °C

2.1: 1,10-Phenanthroline; potassium iodide; copper(I) oxide / methanol; water / 1 h / 80 °C / High pressure

With copper(I) oxide; 1,10-Phenanthroline; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; potassium iodide; In methanol; dichloromethane; water;
DOI:10.1021/ol303164h