2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate

Base Information

Chemical Name:2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate
CAS No.:1422250-79-0
Molecular Formula:C₂₅H₂₁FO₄
Molecular Weight:404.438
Hs Code.:

Synonyms:2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate

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Chemical Property of 2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate

Chemical Property:

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Technology Process of 2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate

There total 4 articles about 2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1422250-63-2
C₁₈H₁₅ClO₄

: 139911-27-6
4-fluoro-3-methylphenyl boronic acid

: 1422250-79-0
2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 8h;
DOI:10.1016/j.tet.2012.12.058

Reference yield:

: 1422251-06-6
3-chloro-4-hydroxyphenethyl methyl carbonate

: 1422250-79-0
2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; silver sulfate / ethanol / 20 °C

2: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 110 °C

3: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 8 h / 100 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iodine; silver sulfate; In 1,4-dioxane; ethanol; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tet.2012.12.058

Reference yield:

: 1422251-05-5
3-chloro-4-hydroxy-5-iodophenethyl methyl carbonate

: 1422250-79-0
2-(7-(4-fluoro-3-methylphenyl)-2-phenylbenzo[b]furan-5-yl)ethyl methyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 110 °C

2: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 8 h / 100 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tet.2012.12.058