1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene

Base Information

• Chemical Name: 1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene
• CAS No.: 483986-88-5
• Molecular Formula: C₃₇H₅₂Si₂
• Molecular Weight: 552.991
• Mol file: 483986-88-5.mol

Synonyms:1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene

Chemical Property of 1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene

There total 1 articles about 1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-triethylsilylacetylene (1777-03-3) + 1,4-bromoiodobenzene (589-87-7) + 1-(tert-butyl)-3-ethynyl-5-[(triisopropylsilyl)ethynyl]benzene (186772-47-4) → 1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene (483986-88-5)

Guidance literature:

2-triethylsilylacetylene; 1,4-bromoiodobenzene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; piperidine; at 20 - 50 ℃;

1-(tert-butyl)-3-ethynyl-5-[(triisopropylsilyl)ethynyl]benzene; at 50 ℃; for 96h; Further stages.;

DOI:10.1021/ol026870y

Reference yield: 83.0%

1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene (483986-88-5) → 1-tert-butyl-3-[2-(4-ethynylphenyl)ethynyl]-5-(2-triisopropylsilylethynyl)benzene (483986-78-3)

Guidance literature:

In tetrahydrofuran; methanol; at 20 ℃; for 96h;

DOI:10.1021/ol026870y

Reference yield:

1-tert-butyl-3-[2-{4-(2-triethylsilylethynyl)phenyl}ethynyl]-5-(2-triisopropylsilylethynyl)benzene (483986-88-5) → 6-[3,5-bis{2-(4-{2-[3-tert-butyl-5-(2-triisopropylsilylethynyl)]phenylethynyl}phenylethynyl)}phenoxy]hexyl benzoate (608527-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / K₂CO₃ / tetrahydrofuran; methanol / 96 h / 20 °C

2: 78 percent / CuI; PPh₃; Et₃N / [Pd₂(dba)3] / 72 h / 20 °C

With copper(l) iodide; potassium carbonate; triethylamine; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol;

DOI:10.1002/chem.200304796

upstream raw materials:

2-triethylsilylacetylene

1,4-bromoiodobenzene

1-(tert-butyl)-3-ethynyl-5-[(triisopropylsilyl)ethynyl]benzene

Downstream raw materials:

1-tert-butyl-3-[2-(4-ethynylphenyl)ethynyl]-5-(2-triisopropylsilylethynyl)benzene

6-[3,5-bis(2-{4-[2-(3-tert-butyl-5-ethynyl)phenylethynyl]phenylethynyl})phenoxy]hexyl benzoate

6-[3,5-bis{2-(4-{2-[3-tert-butyl-5-(2-triisopropylsilylethynyl)]phenylethynyl}phenylethynyl)}phenoxy]hexyl benzoate