2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione

Base Information

• Chemical Name: 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione
• CAS No.: 206071-88-7
• Molecular Formula: C₂₀H₁₇BrO₇
• Molecular Weight: 449.255
• Mol file: 206071-88-7.mol

Synonyms:2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione

Chemical Property of 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione

There total 8 articles about 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-1,4-naphthalenedione (206071-85-4) → 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione (206071-88-7)

Guidance literature:

With sodium hydroxide; In methanol; water; at 50 ℃; for 4.5h;

DOI:10.1016/S0040-4020(00)00551-2

Reference yield: 96.0%

methyl 2-(2'-bromo-4',5'-dimethoxyphenylacetyl)-4,5-dimethoxyphenylacetate (144266-49-9) → 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione (206071-88-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 0.5h; Heating;

DOI:10.1016/S0040-4020(00)00551-2

Reference yield:

1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxyisoquinoline (51449-10-6) → 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione (206071-88-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / acetone / 20 °C

2: 45 percent / NaOH / methanol / Heating

3: 80 percent / Fremy's salt; KH₂PO₄ / H₂O; acetone / 20 °C

4: 98 percent / NaOH / methanol; H₂O / 4.5 h / 50 °C

With sodium hydroxide; potassium dihydrogenphosphate; potassiuim nitrosodisulfonate; In methanol; water; acetone; 1: Alkylation / 2: Ring cleavage / 3: Oxidation / 4: hydroxylation;

DOI:10.1016/S0040-4020(00)00551-2

upstream raw materials:

methyl 2-(2'-bromo-4',5'-dimethoxyphenylacetyl)-4,5-dimethoxyphenylacetate

2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-1,4-naphthalenedione

Papaverine

1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxyisoquinoline