(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt

Base Information

Chemical Name:(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt
CAS No.:135426-77-6
Molecular Formula:C₂₆H₂₇FNO₆P*2Na
Molecular Weight:545.455
Hs Code.:

Synonyms:(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt

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Chemical Property of (S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt

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Technology Process of (S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt

There total 8 articles about (S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 135454-84-1
(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester

: 135426-77-6
(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 55 ℃; for 3h;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135426-77-6
(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt

Guidance literature:: Multi-step reaction with 7 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: 56 percent / pyridine / 16 h / 0 °C

6: 90 percent / AcOH, tetra-N-butylammonium fluoride / tetrahydrofuran / 19 h / Ambient temperature

7: 65 percent / 1N aq. NaOH / dioxane / 3 h / 55 °C

With piperidine; pyridine; sodium hydroxide; lithium aluminium tetrahydride; copper diacetate; ammonium acetate; tetrabutyl ammonium fluoride; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; acetic acid; benzene;
DOI:10.1021/jm00113a019

Reference yield:

: 135426-24-3
5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

: 135426-77-6
(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>hydroxyphosphinyl>-3-hydroxybutanoic acid disodium salt

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / pyridine / 16 h / 0 °C

2: 90 percent / AcOH, tetra-N-butylammonium fluoride / tetrahydrofuran / 19 h / Ambient temperature

3: 65 percent / 1N aq. NaOH / dioxane / 3 h / 55 °C

With pyridine; sodium hydroxide; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00113a019