N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide

Base Information

• Chemical Name: N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide
• CAS No.: 737004-41-0
• Molecular Formula: C₂₄H₃₀N₄O₂
• Molecular Weight: 406.528
• Mol file: 737004-41-0.mol

Synonyms:N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide

Chemical Property of N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide

There total 5 articles about N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{7-[(6-methoxyquinolin-8-yl)amino]-3-aza-1-benzyl-2-oxooctyl}carbamic acid tert-butyl ester (737004-39-6) → N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide (737004-41-0)

Guidance literature:

With trifluoroacetic acid; at 20 ℃;

DOI:10.1016/j.tet.2004.04.077

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide (737004-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N; N,N'-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / 120 h / 20 °C

2: TFA / 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tet.2004.04.077

Reference yield:

3-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-3-benzyl-1,4-diazaspiro[4.4]nonan-2-one (737004-51-2) → N-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-2-amino-3-phenylacetamide (737004-41-0)

Guidance literature:

With phosphate buffer; In acetonitrile; at 37 ℃; pH=7.4;

DOI:10.1016/j.tet.2004.04.077

upstream raw materials:

N-{7-[(6-methoxyquinolin-8-yl)amino]-3-aza-1-benzyl-2-oxooctyl}carbamic acid tert-butyl ester

3-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-3-benzyl-1,4-diazaspiro[4.4]nonan-2-one

3-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-3-benzyl-1,4-diazaspiro[4.5]decan-2-one

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

3-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-5-benzyl-2,2-dimethylimidazolidin-4-one

3-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-3-benzyl-1,4-diazaspiro[4.4]nonan-2-one

3-{4-[(6-methoxyquinolin-8-yl)amino]pentyl}-3-benzyl-1,4-diazaspiro[4.5]decan-2-one

C₃₁H₄₁N₅O₅