(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester

Base Information

Chemical Name:(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester
CAS No.:382596-26-1
Molecular Formula:C₂₃H₂₉NO₆
Molecular Weight:415.486
Hs Code.:
Mol file:382596-26-1.mol

Synonyms:ethyl (2R,3S)-3-(tert-butoxycarbonylamino)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoate

Suppliers and Price of (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-4-(phenylmethoxy)-benzenepropanoicAcidEthylEster
25mg
$ 1410.00

Total 2 raw suppliers

Chemical Property of (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester

Chemical Property:

Storage Temp.:-20°C Freezer
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate

Purity/Quality:

96% ^*data from raw suppliers

(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-4-(phenylmethoxy)-benzenepropanoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester is used in the synthesis of Paclitaxel metabolite.

Technology Process of (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester

There total 3 articles about (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (2R,3S)-3-Amino-3-(4-benzyloxy-phenyl)-2-hydroxy-propionic acid ethyl ester; hydrochloride

: 382596-26-1
ethyl (2R,3S)-3-(tert-butoxycarbonylamino)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1021/jo0102516

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 382596-26-1
ethyl (2R,3S)-3-(tert-butoxycarbonylamino)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / CH₂Cl₂ / 24 h / 20 °C

2.1: K₂[OsO₂(OH)4]; LiOH*H₂O; (DHQ)2PHAL / 2-methyl-propan-2-ol; H₂O; acetonitrile / 24 h / 0 - 5 °C

2.2: HCl / ethanol / 4 h / 90 °C

3.1: 23 g / NaHCO₃ / tetrahydrofuran / 5 h / 20 °C

With lithium hydroxide; Hydroquinone 1,4-phthalazinediyl diether; K2; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol; 1.1: Wittig olefination / 2.1: Sharpless aminohydroxylation;
DOI:10.1021/jo0102516

Reference yield:

: 104315-07-3
(E)-ethyl 3-(4-(benzyloxy)phenyl)acrylate

: 382596-26-1
ethyl (2R,3S)-3-(tert-butoxycarbonylamino)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂[OsO₂(OH)4]; LiOH*H₂O; (DHQ)2PHAL / 2-methyl-propan-2-ol; H₂O; acetonitrile / 24 h / 0 - 5 °C

1.2: HCl / ethanol / 4 h / 90 °C

2.1: 23 g / NaHCO₃ / tetrahydrofuran / 5 h / 20 °C

With lithium hydroxide; Hydroquinone 1,4-phthalazinediyl diether; K2; sodium hydrogencarbonate; In tetrahydrofuran; water; acetonitrile; tert-butyl alcohol; 1.1: Sharpless aminohydroxylation;
DOI:10.1021/jo0102516