2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester
• CAS No.: 852142-49-5
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.328
• Mol file: 852142-49-5.mol

Synonyms:2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester

Chemical Property of 2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester

There total 1 articles about 2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) + 4-n-methylphenylacetylene (766-97-2) → 2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester (852142-49-5)

Guidance literature:

4-n-methylphenylacetylene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

With lead(IV) acetate; In dichloromethane; at -50 - 20 ℃; for 0.416667h;

2-ethoxycarbonyl-1-cyclopentanone; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2005.02.138

Reference yield: 94.0%

2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester (852142-49-5) → 5-ethoxycarbonyl-7-(p-tolyl)-5,6-heptadienoic acid

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2005.02.138

Reference yield: 94.0%

tetrabutylammonium ethoxide (106303-37-1) + 2-oxo-1-p-tolylethynyl-cyclopentanecarboxylic acid ethyl ester (852142-49-5) → ethyl 5-ethoxycarbonyl-7-(p-tolyl)-5,6-heptadienoate

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2005.02.138

upstream raw materials:

2-ethoxycarbonyl-1-cyclopentanone

4-n-methylphenylacetylene