(S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester
CAS No.:214221-07-5
Molecular Formula:C₄₃H₄₇N₃O₆
Molecular Weight:701.863
Hs Code.:

Synonyms:(S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester

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Chemical Property of (S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester

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Technology Process of (S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester

There total 7 articles about (S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37089-77-3
3,3-diphenylpropanoyl chloride

: 214221-07-5
(S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 12 percent / EDCI, HOBt, TEA / CH₂Cl₂ / 12 h / Ambient temperature

3: 1.) MeI; 2.) K₂CO₃ / 1.) r.t., 24 h; 2.) THF, r.t., 16 h

With TEA; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; methyl iodide; In dichloromethane;
DOI:10.1246/cl.1998.943

Reference yield:

: (2R,3S)-1-Acetyl-2-(2-methylsulfanyl-ethyl)-3-phenyl-pyrrolidine-2-carboxylic acid

: 214221-07-5
(S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / HCl / acetic acid / 24 h / 100 °C

2: 64 percent / Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

3: 12 percent / EDCI, HOBt, TEA / CH₂Cl₂ / 12 h / Ambient temperature

4: 1.) MeI; 2.) K₂CO₃ / 1.) r.t., 24 h; 2.) THF, r.t., 16 h

With hydrogenchloride; TEA; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; methyl iodide; In dichloromethane; acetic acid;
DOI:10.1246/cl.1998.943

Reference yield:

: 214220-96-9
1-Acetyl-5-hydroxy-2-(2-methylsulfanyl-ethyl)-3-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

: 214221-07-5
(S)-6-Benzyloxycarbonylamino-2-[(4R,5S)-1-(3,3-diphenyl-propionyl)-6-oxo-4-phenyl-1,7-diaza-spiro[4.4]non-7-yl]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / Et₃SiH, CF₃CO₂H / 1 h / 10 °C

2: 57 percent / NaOH / ethanol / 72 h / Heating

3: 86 percent / HCl / acetic acid / 24 h / 100 °C

4: 64 percent / Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

5: 12 percent / EDCI, HOBt, TEA / CH₂Cl₂ / 12 h / Ambient temperature

6: 1.) MeI; 2.) K₂CO₃ / 1.) r.t., 24 h; 2.) THF, r.t., 16 h

With hydrogenchloride; triethylsilane; sodium hydroxide; TEA; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; methyl iodide; In ethanol; dichloromethane; acetic acid;
DOI:10.1246/cl.1998.943