N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide

Base Information

Chemical Name:N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide
CAS No.:1307271-36-8
Molecular Formula:C₂₁H₂₅ClN₆O₂S₂
Molecular Weight:493.054
Hs Code.:

Synonyms:N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide

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Chemical Property of N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide

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Technology Process of N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide

There total 8 articles about N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1307272-74-7
1,1-dimethylethyl 4-(5-(2-amino-4-pyrimidinyl)-4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-1-piperidinecarboxylate

: 1307271-36-8
N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 120100-15-4
methyl 3-amino-2-chlorobenzoate

: 1307271-36-8
N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 6.5 h / 0 - 30 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - -10 °C / Inert atmosphere

2.2: -10 - 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1.33 h / 20 °C / Inert atmosphere

3.2: 72 h / 20 °C / Inert atmosphere

4.1: ammonium hydroxide / water / 1.5 h / 90 °C / Inert atmosphere; Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With pyridine; ammonium hydroxide; N-Bromosuccinimide; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; water;

Reference yield:

: 214834-18-1
tert-butyl 4-carbamothioylpiperidine-1-carboxylate

: 1307271-36-8
N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-chlorophenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1.33 h / 20 °C / Inert atmosphere

1.2: 72 h / 20 °C / Inert atmosphere

2.1: ammonium hydroxide / water / 1.5 h / 90 °C / Inert atmosphere; Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With ammonium hydroxide; N-Bromosuccinimide; trifluoroacetic acid; In dichloromethane; ISOPROPYLAMIDE; water;