benzyl N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoate

Base Information

• Chemical Name: benzyl N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoate
• CAS No.: 1415221-97-4
• Molecular Formula: C₄₁H₄₆N₂O₅
• Molecular Weight: 646.827
• Mol file: 1415221-97-4.mol

Synonyms:benzyl N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoate

Chemical Property of benzyl N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of benzyl N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoate

There total 1 articles about benzyl N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Orn-OBn + 8-phenyloctanoic acid (26547-51-3) → benzyl N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoate (1415221-97-4)

Guidance literature:

8-phenyloctanoic acid; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

Fmoc-Orn-OBn; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.10.093

Reference yield:

benzyl N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoate (1415221-97-4) → N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoic acid (1415221-88-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 1h;

DOI:10.1016/j.bmcl.2012.10.093

upstream raw materials:

8-phenyloctanoic acid

Downstream raw materials:

N--Fmoc--(2S)--2--amino--5--(8--phenyloctanamido)pentanoic acid