2-(2-bromophenyl)-2-methylpropionaldehyde

Base Information

• Chemical Name: 2-(2-bromophenyl)-2-methylpropionaldehyde
• CAS No.: 212626-89-6
• Molecular Formula: C₁₀H₁₁BrO
• Molecular Weight: 227.101
• Mol file: 212626-89-6.mol

Synonyms:2-(2-bromophenyl)-2-methylpropionaldehyde

Chemical Property of 2-(2-bromophenyl)-2-methylpropionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(2-bromophenyl)-2-methylpropionaldehyde

There total 3 articles about 2-(2-bromophenyl)-2-methylpropionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(2-bromophenyl)-2-methylpropanenitrile (57775-06-1) → 2-(2-bromophenyl)-2-methylpropionaldehyde (212626-89-6)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; 1.) -70 deg C, 30 min, 2.) room temperature, 1 h;

DOI:10.1021/jo980697v

Reference yield:

2-(2-bromophenyl)-2-methylpropan-1-ol (177748-64-0) → 2-(2-bromophenyl)-2-methylpropionaldehyde (212626-89-6)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/jacs.8b02761

Reference yield:

methyl 2-(2-bromophenyl)-2-methylpropanoate (177748-63-9) → 2-(2-bromophenyl)-2-methylpropionaldehyde (212626-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 - -25 °C

2: pyridinium chlorochromate / dichloromethane / 3 h / 0 - 20 °C

With diisobutylaluminium hydride; pyridinium chlorochromate; In dichloromethane; toluene;

DOI:10.1021/jacs.8b02761

upstream raw materials:

2-(2-bromophenyl)-2-methylpropanenitrile

methyl 2-(2-bromophenyl)-2-methylpropanoate

2-(2-bromophenyl)-2-methylpropan-1-ol

Downstream raw materials:

8,8-dimethylbicyclo[4.2.0]octa-1,3,5-trien-7-one

isopropenylbenzene

methyl 2-methyl-2-phenylpropionate