2'-Monodehydroxy-2'-chloro Ganciclovir

Base Information

• Chemical Name: 2'-Monodehydroxy-2'-chloro Ganciclovir
• CAS No.: 108436-36-8
• Molecular Formula: C₉H₁₂ClN₅O₃
• Molecular Weight: 273.679
• Mol file: 108436-36-8.mol

Synonyms:9-<<2-chloro-1-(hydroxymethyl)ethoxy>methyl>guanine

Chemical Property of 2'-Monodehydroxy-2'-chloro Ganciclovir

Chemical Property:

• Melting Point: 270 °C
• PKA: 9.32±0.20(Predicted)
• Density: 1.79±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO, Methanol (Sparingly)

Purity/Quality:

99%, ^*data from raw suppliers

2’-Monodehydroxy-2’-chloroGanciclovir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2’-Monodehydroxy-2’-chloro Ganciclovir is an Impurity of Ganciclovir (G235000). 2’-Monodehydroxy-2’-chloro Ganciclovir is a sugar modified acyclic analogue of guanosine (G837900). Studies have shown 2’-Monodehydroxy-2’-chloro Ganciclovir has potential to exhibit virucidal activity. 2’-Monodehydroxy-2’-chloro Ganciclovir is an Impurity of Ganciclovir (G235000). 2’-Monodehydroxy-2’-chloro Ganciclovir is a sugar modified acyclic analogue of guanosine (G837900). Studies have shown 2’-Monodehydroxy-2’-chloro Ganciclovir has potential to exhibit virucidal activity. Iso mono chloro ganciclovir

Technology Process of 2'-Monodehydroxy-2'-chloro Ganciclovir

There total 5 articles about 2'-Monodehydroxy-2'-chloro Ganciclovir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H16ClN5O5 → 9-<<2-chloro-1-(hydroxymethyl)ethoxy>methyl>guanine (108436-36-8)

Guidance literature:

With methanol; ammonium hydroxide; at 50 - 60 ℃; for 4h; Reagent/catalyst;

Reference yield:

N-[9-(2-Benzyloxy-1-chloromethyl-ethoxymethyl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-acetamide (103024-99-3) → 9-<<2-chloro-1-(hydroxymethyl)ethoxy>methyl>guanine (108436-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, conc. HCl / 10percent Pd/C / methanol; H₂O / 96 h / 50 Torr

2: conc. NH₄OH / methanol / 18 h / Ambient temperature

With hydrogenchloride; ammonium hydroxide; hydrogen; palladium on activated charcoal; In methanol; water;

DOI:10.1021/jm00158a011

Reference yield:

N-[9-(2-Chloro-1-hydroxymethyl-ethoxymethyl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-acetamide → 9-<<2-chloro-1-(hydroxymethyl)ethoxy>methyl>guanine (108436-36-8)

Guidance literature:

With ammonium hydroxide; In methanol; for 18h; Yield given; Ambient temperature;

DOI:10.1021/jm00158a011

upstream raw materials:

1-chloro-3-benzoyloxy-2-chloromethoxypropane

N-[9-(2-Benzyloxy-1-chloromethyl-ethoxymethyl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-acetamide

guanine

Downstream raw materials:

2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-N-(benzyloxy carbonyl)-L-valinate