5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde

Base Information

Chemical Name:5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde
CAS No.:1206833-05-7
Molecular Formula:C₃₁H₂₇NO₃S₂
Molecular Weight:525.692
Hs Code.:

Synonyms:5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde

Suppliers and Price of 5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde

There total 3 articles about 5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1206833-01-3
4-(methoxymethyl)-N-(4-(methoxymethyl)phenyl)-N-(4-(5-(5-(5,5-dimethyl-1,3-dioxan-2-yl)thiophen-2-yl)thiophen-2-yl)phenyl)benzenamine

: 1206833-05-7
5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde

Guidance literature:: 4-(methoxymethyl)-N-(4-(methoxymethyl)phenyl)-N-(4-(5-(5-(5,5-dimethyl-1,3-dioxan-2-yl)thiophen-2-yl)thiophen-2-yl)phenyl)benzenamine; With trifluoroacetic acid; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;

With sodium hydrogencarbonate; In tetrahydrofuran; water; Inert atmosphere;
DOI:10.1021/ol9026182

Reference yield:

: 1372699-62-1
2-(5'-bromo-2,2'-bithiophen-5-yl)-5,5-dimethyl-1,3-dioxane

: 1206833-05-7
5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique

1.2: Inert atmosphere; Schlenk technique

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / Inert atmosphere; Reflux; Schlenk technique

3.1: tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate / 12 h / 110 °C / Inert atmosphere; Schlenk technique

4.1: trifluoroacetic acid / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere; Schlenk technique

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; In tetrahydrofuran; hexane; water; 2.1: |Suzuki Coupling / 3.1: |Buchwald-Hartwig Coupling;
DOI:10.1002/chem.201201500

Reference yield:

: 1206832-99-6
4-[5'-(5,5-dimethyl-1,3-dioxan-2-yl)[2,2'-bithiophen]-5-yl]benzenamine

: 1206833-05-7
5'-{4-[bis-(4-methoxymethyl-phenyl)-amino]-phenyl}-[2,2']bithiophene-5-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate / 12 h / 110 °C / Inert atmosphere; Schlenk technique

2: trifluoroacetic acid / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere; Schlenk technique

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; In tetrahydrofuran; water; 1: |Buchwald-Hartwig Coupling;
DOI:10.1002/chem.201201500