(R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Base Information

Chemical Name:(R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS No.:1260846-57-8
Molecular Formula:C₂₁H₂₂F₂N₄O₂
Molecular Weight:400.428
Hs Code.:

Synonyms:(R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Chemical Property of (R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Technology Process of (R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

There total 3 articles about (R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1224944-77-7
5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

: 1260846-56-7
(R)-5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidine hydrochloride

: 1260846-57-8
(R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 160 ℃; for 120h; sealed tube;

Reference yield:

: 6994-25-8,103259-35-4,19750-02-8
3-amino-4-pyrazolecarboxylic acid ethyl ester

: 1260846-57-8
(R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 110 °C

1.2: 20 °C / pH 4

2.1: trichlorophosphate / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 120 h / 160 °C / sealed tube

With caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 926663-00-5
5-hydroxypyrazole[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

: 1260846-57-8
(R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 120 h / 160 °C / sealed tube

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In isopropyl alcohol;