(4R)-4-methoxymethoxy-oct-7-enoic acid

Base Information

Chemical Name:(4R)-4-methoxymethoxy-oct-7-enoic acid
CAS No.:865091-23-2
Molecular Formula:C₁₀H₁₈O₄
Molecular Weight:202.251
Hs Code.:

Synonyms:(4R)-4-methoxymethoxy-oct-7-enoic acid

Suppliers and Price of (4R)-4-methoxymethoxy-oct-7-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R)-4-methoxymethoxy-oct-7-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R)-4-methoxymethoxy-oct-7-enoic acid

There total 1 articles about (4R)-4-methoxymethoxy-oct-7-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 865091-23-2
(4R)-4-methoxymethoxy-oct-7-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / pyridine / CHCl₃ / 12 h / 0 °C

2.1: BH₃*DMS / tetrahydrofuran / 0 - 20 °C

2.2: 79 percent / imidazole / dimethylformamide / 15 h / 20 °C

3.1: tetrahydrofuran / -78 - 20 °C

3.2: 90 percent / ethyldiisopropylamine; DMAP; tetra-n-butylammonium iodide / CH₂Cl₂ / 96 h

4.1: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 - 20 °C

5.1: 60 percent / TEMPO; NaClO₂; NaH₂PO₄ buffer / acetonitrile; H₂O / 20 h / 45 °C / pH 6.6

With pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; dimethylsulfide borane complex; NaH₂PO₄ buffer; tetrabutyl ammonium fluoride; In tetrahydrofuran; chloroform; water; acetonitrile;
DOI:10.1021/ol051483k

Reference yield:

: 865091-23-2
(4R)-4-methoxymethoxy-oct-7-enoic acid

: (10R,13R)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-propyl]-4,10,13-tris-methoxymethoxy-13-[(2R,5R)-5-((S)-1-methoxymethoxy-pentadecyl)-tetrahydro-furan-2-yl]-tridecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 98 percent / DMAP; DCC / CH₂Cl₂ / 15 h / 20 °C

2.1: 95 percent / Dibal-H / tetrahydrofuran; toluene / 1 h / -78 °C

3.1: (+)-B-methoxy(diisopinocamphenyl)borane / diethyl ether / 2.5 h / 20 °C

3.2: 78 percent / diethyl ether / 2.5 h / -100 °C

4.1: Hunig's base

5.1: 89 percent / second generation Grubbs' catalyst / CH₂Cl₂ / 5 h / Heating

6.1: 100 percent / hydrogen / Pd/C / methanol / 5 h / 20 °C

7.1: 95 percent / NaOMe / 3 h / Heating

8.1: 86 percent / DMAP; ethyldiisopropylamine / CH₂Cl₂ / 0 - 20 °C

9.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

9.2: tetrahydrofuran / 2 h / -78 °C

With dmap; hydrogen; sodium methylate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; (+)-B-methoxydiisocamphenylborane; lithium diisopropyl amide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; 3.2: Racherla-Brown asymmetric allylation;
DOI:10.1021/ol051483k

Reference yield:

: 865091-23-2
(4R)-4-methoxymethoxy-oct-7-enoic acid

: 865091-32-3
(5R,11R)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-propyl]-5-methoxymethoxy-11-{(R)-3-methoxymethoxy-3-[(2R,5R)-5-((S)-1-methoxymethoxy-pentadecyl)-tetrahydro-furan-2-yl]-propyl}-oxacycloundecan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / DMAP; DCC

2.1: 89 percent / first generation Grubbs' catalyst / CH₂Cl₂ / 18 h / Heating

3.1: 100 percent / hydrogen / Pd/C / ethyl acetate / 18 h

4.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

4.2: tetrahydrofuran / 2 h / -78 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ol051483k