Technology Process of ALL CIS-7,10,13,16,19-DOCOSAPENTAENOIC ACID ETHYL ESTER
There total 4 articles about ALL CIS-7,10,13,16,19-DOCOSAPENTAENOIC ACID ETHYL ESTER which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,6-di-tert-butyl-4-methyl-phenol; propionic acid;
for 38h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 20 °C / Cooling with ice
2.1: pyridine / 5 h / 1 - 5 °C / Inert atmosphere
3.1: lithium iodide / acetone / 4 h / Molecular sieve; Inert atmosphere; Reflux
4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
4.2: 6 h / 70 - 80 °C
5.1: 2,6-di-tert-butyl-4-methyl-phenol; propionic acid / 38 h / Inert atmosphere; Reflux
With
pyridine; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methyl-phenol; sodium hydride; propionic acid; lithium iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / 5 h / 1 - 5 °C / Inert atmosphere
2.1: lithium iodide / acetone / 4 h / Molecular sieve; Inert atmosphere; Reflux
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
3.2: 6 h / 70 - 80 °C
4.1: 2,6-di-tert-butyl-4-methyl-phenol; propionic acid / 38 h / Inert atmosphere; Reflux
With
pyridine; 2,6-di-tert-butyl-4-methyl-phenol; sodium hydride; propionic acid; lithium iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
