{2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester

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Chemical Name:{2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester
CAS No.:135685-09-5
Molecular Formula:C₁₆H₂₆N₄O₇S
Molecular Weight:418.471
Hs Code.:

Synonyms:{2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester

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Chemical Property of {2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester

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Technology Process of {2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester

There total 7 articles about {2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 135685-08-4
N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(phthalimidooxy)methyl>benzenesulfonamide

: 135685-09-5
{2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: With hydrazine; In ethanol; at 80 ℃; for 3h;
DOI:10.1021/jm00114a024

Reference yield:

: 2-(4-Amino-2-nitro-benzyloxy)-isoindole-1,3-dione

: 135685-09-5
{2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaNO₂, conc. aq. HCl, AcOH, 2.) SO₂, aq. CuCl₂ / 1.) -5 deg C - deg C, 15 min, 2.) from 0 deg C to RT, 3 h

2: 81.9 percent / N,N-diisopropylethylamine / tetrahydrofuran / 3.5 h / 0 - 20 °C

3: 46 percent / hydrazine / ethanol / 3 h / 80 °C

With hydrogenchloride; sulfur dioxide; acetic acid; N-ethyl-N,N-diisopropylamine; copper dichloride; hydrazine; sodium nitrite; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a024

Reference yield:

: 135685-05-1
N,N-bis<(tert-butyloxy)carbonyl>-4-methyl-3-nitroaniline

: 135685-09-5
{2-[(4-Aminooxymethyl-3-nitro-benzenesulfonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-bromosuccinimide (NBS), dibenzoyl peroxide / CCl₄ / 20 h / Heating; Irradiation

2: Et₃N / acetonitrile / 6 h / Heating

3: CF₃CO₂H / CH₂Cl₂ / 0 - 6 °C

4: 1.) NaNO₂, conc. aq. HCl, AcOH, 2.) SO₂, aq. CuCl₂ / 1.) -5 deg C - deg C, 15 min, 2.) from 0 deg C to RT, 3 h

5: 81.9 percent / N,N-diisopropylethylamine / tetrahydrofuran / 3.5 h / 0 - 20 °C

6: 46 percent / hydrazine / ethanol / 3 h / 80 °C

With hydrogenchloride; N-Bromosuccinimide; sulfur dioxide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper dichloride; hydrazine; sodium nitrite; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00114a024