N-benzhydryl-3,4-dimethoxybenzamide

Base Information

• Chemical Name: N-benzhydryl-3,4-dimethoxybenzamide
• CAS No.: 127568-43-8
• Molecular Formula: C₂₂H₂₁NO₃
• Molecular Weight: 347.414
• Mol file: 127568-43-8.mol

Synonyms:N-benzhydryl-3,4-dimethoxybenzamide

Chemical Property of N-benzhydryl-3,4-dimethoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzhydryl-3,4-dimethoxybenzamide

There total 3 articles about N-benzhydryl-3,4-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

Benzhydrylamine (91-00-9) + 3,4-dimethoxybenzoic acid chloride (3535-37-3) → N-benzhydryl-3,4-dimethoxybenzamide (127568-43-8)

Guidance literature:

With pyridine; In benzene; for 1h; Heating;

DOI:10.1007/BF00764709

Reference yield:

1,1-Diphenylmethanol (91-01-0) + veratronitrile (2024-83-1) → N-benzhydryl-3,4-dimethoxybenzamide (127568-43-8)

Guidance literature:

1,1-Diphenylmethanol; veratronitrile; With tetrafluoroboric acid diethyl ether; at 20 ℃; for 2h;

With water; sodium hydrogencarbonate; at 20 ℃;

DOI:10.1055/s-0034-1380754

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → N-benzhydryl-3,4-dimethoxybenzamide (127568-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide; tetrafluoroboric acid diethyl ether; acetic acid / 1 h / 20 °C

2.1: tetrafluoroboric acid diethyl ether / 2 h / 20 °C

2.2: 20 °C

With tetrafluoroboric acid diethyl ether; sodium azide; acetic acid; 1.1: |Schmidt Reaction / 2.1: |Ritter Amidation;

DOI:10.1055/s-0034-1380754

upstream raw materials:

Benzhydrylamine

3,4-dimethoxybenzoic acid chloride

3,4-dimethoxy-benzaldehyde

1,1-Diphenylmethanol