N-ACETYL-5-BROMOTRYPTAMINE

Base Information

• Chemical Name: N-ACETYL-5-BROMOTRYPTAMINE
• CAS No.: 119623-06-2
• Molecular Formula: C12H13 Br N2 O
• Molecular Weight: 281.152
• Mol file: 119623-06-2.mol

Synonyms:UCM 245

Chemical Property of N-ACETYL-5-BROMOTRYPTAMINE

Chemical Property:

• PSA: 48.38000
• LogP: 3.44930

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ACETYL-5-BROMOTRYPTAMINE

There total 4 articles about N-ACETYL-5-BROMOTRYPTAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N-[(methyl)carbonyl]-2-pyrroline (23105-58-0) + 4-bromo-2-methoxyphenylhydrazine hydrochloride (1353636-61-9) → N-(2-(5-bromo-7-methoxyindol-3-yl)ethyl)acetamide (1383939-51-2) + N-(2-(5-bromo-1-((4-bromo-2-methoxyphenyl)amino)indol-3-yl)ethyl)acetamide (1383939-52-3) + N-[2-(5-bromo-1H-indol-3-yl)ethyl]acetamide (119623-06-2)

Guidance literature:

With acetic acid; In water; ethyl acetate; at 70 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.05.029

Reference yield: 51.0%

Nb-acetyl-1-(2-methoxycarbonyl)ethoxytryptamine (258267-48-0) → N-Acetyltryptamine (1016-47-3) + N-[2-(2-oxoindolin-3-yl)ethyl]acetamide (70638-13-0) + N-[2-(5-bromo-1H-indol-3-yl)ethyl]acetamide (119623-06-2) + N-[2-(7-bromo-1H-indol-3-yl)-ethyl]-acetamide (258267-54-8)

Guidance literature:

With hydrogen bromide; In methanol; water; at 20 ℃; for 20h;

DOI:10.3987/com-99-8721

Reference yield: 38.0%

Nb-acetyl-1-(2-methoxycarbonyl-1-methyl)ethoxytryptamine (258267-49-1) → N-Acetyltryptamine (1016-47-3) + N-[2-(5-bromo-1H-indol-3-yl)ethyl]acetamide (119623-06-2) + N-[2-(7-bromo-1H-indol-3-yl)-ethyl]-acetamide (258267-54-8)

Guidance literature:

With hydrogen bromide; In methanol; water; at 20 ℃; for 55h;

DOI:10.3987/com-99-8721

upstream raw materials:

Nb-acetyl-1-hydroxytryptamine

Nb-acetyl-1-(2-methoxycarbonyl)ethoxytryptamine

Nb-acetyl-1-(2-methoxycarbonyl-1-methyl)ethoxytryptamine

N-[(methyl)carbonyl]-2-pyrroline

Downstream raw materials:

N-[2-(5-phenyl-1H-indol-3-yl)-ethyl]-acetamide

N-(2-(5-mesityl-1-methyl-1H-indol-3-yl)ethyl)acetamide

Refernces

• 1、 Hasegawa, Masakazu,Yamada, Koji,Nagahama, Yoshiyuki,Somei, Masanori. "A novel methodology for preparing 5-chloro- and 5-bromotryptamines and tryptophans, and its application to the synthesis of (±)-bromochelonin B". . p. 2815 - 2821. Retrieved 2007/10/03.