2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide

Base Information

Chemical Name:2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide
CAS No.:1394824-66-8
Molecular Formula:C₂₂H₂₆F₃N₇O₃
Molecular Weight:493.489
Hs Code.:

Synonyms:2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide

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Chemical Property of 2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide

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Technology Process of 2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide

There total 6 articles about 2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

: 1394824-64-6
C₂₄H₂₈F₃N₅O₄

: 1394824-66-8
2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide

Guidance literature:: With hydrazine hydrate; In ethanol; at 50 ℃; for 48h;
DOI:10.1248/cpb.c12-00234

Reference yield:

: 1394824-61-3
2-(piperazin-1-yl)-N-(4-(3-(3-trifluoromethyl)phenylureido)phenyl)acetamide

: 1394824-66-8
2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: alkaline carbonate / ethanol / 50 - 65 °C

2: hydrazine hydrate / ethanol / 48 h / 50 °C

With hydrazine hydrate; In ethanol;
DOI:10.1248/cpb.c12-00234

Reference yield:

: 100-28-7
4-Nitrophenyl isocyanate

: 1394824-66-8
2-(4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)-N-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 20 °C

2: iron; ammonium chloride; acetic acid / ethanol / 5 h / 80 °C

3: triethylamine / dichloromethane / 5 h / 0 - 20 °C / Cooling with ice

4: ethanol / 6 h / 20 °C

5: alkaline carbonate / ethanol / 50 - 65 °C

6: hydrazine hydrate / ethanol / 48 h / 50 °C

With iron; ammonium chloride; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1248/cpb.c12-00234