*,R^*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt

Base Information

• Chemical Name: *,R^*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt
• CAS No.: 126110-66-5
• Molecular Formula: C₂₃H₃₃N₂O₆PS₂*2Li
• Molecular Weight: 542.513

Synonyms:*,R^*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt

Chemical Property of *,R^*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt

Chemical Property:

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Technology Process of *,R^*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt

There total 9 articles about *,R^*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

*,R*)>-7-<2-<oxy>-1-oxo-6-<(trifluoroacetyl)amino>hexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid methyl ester (126110-86-9) → *,R*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt (126110-66-5)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; for 2.5h; Ambient temperature;

DOI:10.1021/jm00167a028

Reference yield:

(S)-6-Amino-2-hydroxyhexanoic acid (42491-84-9) → *,R*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt (126110-66-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) bis(trimethylsilyl)trifluoroacetamide / 1.) acetonitrile, room temp., 2 h

2: potassium carbonate / dimethylformamide / 5 h / Ambient temperature

3: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

4: NaIO₄ / dioxane; H₂O / 18 h / Ambient temperature

5: H₂ / 10percent Pd/C / methanol; H₂O / 2 h / 1551.4 Torr

6: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

7: triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temp., 2 h

8: 80 percent / 1.0 N LiOH / dioxane / 2.5 h / Ambient temperature

With dmap; lithium hydroxide; sodium periodate; bis(trimethylsilyl)trifluoroacetamide; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00167a028

Reference yield:

(4-phenylbutyl)phosphinic acid (86552-32-1) → *,R*)>-7-<6-amino-2-<oxy>-1-oxohexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid dilithium salt (126110-66-5)

Guidance literature:

Multi-step reaction with 6 steps

1: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 18 h / Ambient temperature

3: H₂ / 10percent Pd/C / methanol; H₂O / 2 h / 1551.4 Torr

4: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

5: triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temp., 2 h

6: 80 percent / 1.0 N LiOH / dioxane / 2.5 h / Ambient temperature

With dmap; lithium hydroxide; sodium periodate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water;

DOI:10.1021/jm00167a028

upstream raw materials:

*,R^*)>-7-<2-<oxy>-1-oxo-6-<(trifluoroacetyl)amino>hexyl>-1,4-dithia-7-azaspiro<4.4>nonane-8-carboxylic acid methyl ester

(S)-6-Amino-2-hydroxyhexanoic acid

(4-phenylbutyl)phosphinic acid

(S)-2-hydroxy-6<(trifluoroacetyl)amino>hexanoic acid

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