(E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)piperazine

Base Information

• Chemical Name: (E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)piperazine
• CAS No.: 1433605-57-2
• Molecular Formula: C₃₁H₃₈FN₇O₃
• Molecular Weight: 575.686
• Mol file: 1433605-57-2.mol

Synonyms:(E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)piperazine

Chemical Property of (E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)piperazine

There total 2 articles about (E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime (1433605-21-0) + tert-butyl 4-(2-bromoethyl)-piperazine-1-carboxylate (655225-01-7) → (E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)piperazine (1433605-57-2)

Guidance literature:

(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.0833333h; Inert atmosphere;

tert-butyl 4-(2-bromoethyl)-piperazine-1-carboxylate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (77279-24-4) → (E)-N-Boc-4-(((2-(2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)piperazine (1433605-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With carbon tetrabromide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate

(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

tert-butyl 4-(2-bromoethyl)-piperazine-1-carboxylate