benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
CAS No.:1404217-37-3
Molecular Formula:C₄₅H₅₂NO₈PSi
Molecular Weight:793.969
Hs Code.:

Synonyms:benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

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Chemical Property of benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

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Technology Process of benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

There total 7 articles about benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404217-36-2
benzyl (4R,5S)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-5-(hydroxymethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1404217-37-3
benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: benzyl (4R,5S)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-5-(hydroxymethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In acetonitrile; at 20 ℃; Cooling with ice;

With 3-chloro-benzenecarboperoxoic acid; In acetonitrile; at 20 ℃; Cooling with ice;

Reference yield:

: 177186-42-4
(2S,3R)-3-amino-4-tert-butyldiphenylsilyloxy-1,2-isopropylidenedioxy-butane

: 1404217-37-3
benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 48 h

2.1: acetic acid / water; tetrahydrofuran / 5 h / 50 °C

3.1: pyridine / dichloromethane / 0.5 h / Cooling with acetone-dry ice

4.1: toluene-4-sulfonic acid / acetone / 3 h / 50 °C

5.1: sodium methylate; methanol / 1 h

6.1: 1H-tetrazole / acetonitrile / 20 °C / Cooling with ice

6.2: 20 °C / Cooling with ice

With pyridine; 1H-tetrazole; methanol; sodium methylate; sodium hydrogencarbonate; acetic acid; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;

Reference yield:

: 1404217-32-8
benzyl N-[(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl]carbamate

: 1404217-37-3
benzyl (4R,5S)-5-({[bis(benzyloxy)phosphoryl]oxy}methyl)-4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / water; tetrahydrofuran / 5 h / 50 °C

2.1: pyridine / dichloromethane / 0.5 h / Cooling with acetone-dry ice

3.1: toluene-4-sulfonic acid / acetone / 3 h / 50 °C

4.1: sodium methylate; methanol / 1 h

5.1: 1H-tetrazole / acetonitrile / 20 °C / Cooling with ice

5.2: 20 °C / Cooling with ice

With pyridine; 1H-tetrazole; methanol; sodium methylate; acetic acid; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;