diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate

Base Information

Chemical Name:diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate
CAS No.:1621006-31-2
Molecular Formula:C₁₇H₂₂ClN₂O₆P
Molecular Weight:416.798
Hs Code.:

Synonyms:diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate

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Chemical Property of diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate

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Technology Process of diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate

There total 5 articles about diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1621006-25-4
1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrole-3-carbaldehyde

: 122-52-1
triethyl phosphite

: 1621006-31-2
diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate

Guidance literature:: With ammonium metavanadate; In water; at 50 ℃; for 0.333333h; Reflux;
DOI:10.1016/j.ejmech.2014.06.053

Reference yield:

: 1204-35-9
N-(3-chlorophenyl)maleimide

: 1621006-31-2
diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / tetrachloromethane / 25 °C / Reflux

2.1: N,N-dimethyl-formamide / 0.5 h / 10 °C

3.1: trichlorophosphate / 0 °C

3.2: 0.5 h / 0 - 5 °C

4.1: ammonium metavanadate / water / 0.33 h / 50 °C / Reflux

With ammonium metavanadate; bromine; trichlorophosphate; In tetrachloromethane; water; N,N-dimethyl-formamide; 3.1: |Vilsmeier-Haack Formylation / 3.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2014.06.053

Reference yield:

: 1621006-19-6
1-(3-chlorophenyl)-3-(dimethylamino)-1H-pyrrole-2,5-dione

: 1621006-31-2
diethyl (1-(3-chlorophenyl)-4-(dimethylamino)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl)(hydroxy)methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0 °C

1.2: 0.5 h / 0 - 5 °C

2.1: ammonium metavanadate / water / 0.33 h / 50 °C / Reflux

With ammonium metavanadate; trichlorophosphate; In water; 1.1: |Vilsmeier-Haack Formylation / 1.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2014.06.053