(1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Base Information

Chemical Name:(1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
CAS No.:942190-76-3
Molecular Formula:C₁₆H₂₁BrN₂O₂
Molecular Weight:353.259
Hs Code.:

Synonyms:(1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

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Chemical Property of (1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

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Technology Process of (1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

There total 2 articles about (1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 106-37-6
1.4-dibromobenzene

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 942190-76-3
(1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 16h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2015.03.025

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 942190-76-3
(1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: With 18-crown-6 ether; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield: 58.0%

: 942190-76-3
(1S,4S)-tert-butyl 5-(4-bromophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

: 98-80-6
phenylboronic acid

: (1S,4S)-tert-butyl 5-([1,1'-biphenyl]-4-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 20 ℃; for 18h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2015.03.025