(2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate
CAS No.:1381990-76-6
Molecular Formula:C₂₇H₃₃N₃O₅
Molecular Weight:479.576
Hs Code.:

Synonyms:(2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate

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Chemical Property of (2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate

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Technology Process of (2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate

There total 3 articles about (2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1381990-70-0
(2S,4R)-benzyl-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]-4-hydroxypyrrolidine-1-carboxylate

: 111-36-4
n-butyl isocyanide

: 1381990-76-6
(2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; acetonitrile; at 85 ℃; Inert atmosphere;
DOI:10.1039/c2gc35227c

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1381990-76-6
(2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2: tetrahydrofuran / 0 °C / Reflux

3: triethylamine / N,N-dimethyl-formamide; acetonitrile / 85 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c2gc35227c

Reference yield:

: C₁₆H₁₉NO₇

: 1381990-76-6
(2S,4R)-benzyl-4-((butylcarbamoyl)oxy)-2-[((R)-2,3-dihydro-1H-inden-1-yl)carbamoyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 °C / Reflux

2: triethylamine / N,N-dimethyl-formamide; acetonitrile / 85 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c2gc35227c